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    Archived pages: 10 . Archive date: 2014-02.

  • Title: EUROBIOSYN - A modular platform for biosynthesis of complex molecules
    Descriptive info: .. home |.. imprint |.. contact.. home.. partners.. work-packages.. publications.. news-press.. internal.. WELCOME to the home of eurobiosyn.. Economic synthesis of mono- and oligosaccharides represents a pressing, formidable and essentially unresolved challenge of strategic importance against the background of the emerging field of glycomics and the increasing importance of (oligo)saccharide structures in  ...   of their unmatched selectivity.. However, designing a scheme from monosaccharide to oligosaccharide synthesis will require an enzymatic reaction network of sub-cellular proportion that mimics cell metabolism's complexity, dynamic behaviour and energy requirements.. More.. This project is funded by the European Commission within the FP6-NEST-Pathfinder Synthetic Biology.. visit.. site.. 2005 ETH Zürch.. ^ top..

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  • Title: EUROBIOSYN - A modular platform for biosynthesis of complex molecules
    Descriptive info: imprint.. Details about responsibilities according to the offical WWW ETH statements.. editor:.. Michael Schümperli.. ETH Zurich.. Institute of Process Engineering.. Universitätsstr.. 6.. 8092 Zurich.. external links:.. Die Verantwortlichkeit für die in dieser Homepage verlinkten externen Internet- seiten liegt beim jeweiligen externen Anbieter.. Die externen Inhalte wurden beim  ...   Inhalte im Nachhinein von den jeweiligen Anbietern verändert werden.. Sollten Sie der Ansicht sein, dass die verlinkten externen Seiten gegen geltendes Recht ver- stoßen oder sonst unangemessene Inhalte haben, so teilen Sie uns dies bitte mit.. web-site:.. optimized for IE 6.. 0.. resolution 1024x800.. Site by JRZwebdesign..

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  • Title: EUROBIOSYN - A modular platform for biosynthesis of complex molecules
    Descriptive info: Project Coordinator.. Prof.. Sven Panke.. Sonneggstr.. 5.. Switzerland.. Email:.. panke@ipe.. mavt.. ethz.. ch.. Phone: ++41 44 6320413.. Fax: ++41 44 6321325.. Dr.. -Ing.. Matthias Heinemann.. heinemann@ipe.. Phone: +41 44 632 63 66.. Fax: +41 44 632 13 25..

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  • Title: EUROBIOSYN - A modular platform for biosynthesis of complex molecules
    Descriptive info: Institute of Process Engineering, Bioprocess Lab, ETH Zürich, Switzerland.. Institute of Technical Biochemistry, Bioinformatics, Stuttgart University, German.. Department of Chemical Engineering, Technical University of Denmark, Denmark.. Centro Nacional de Biotechnologia, Madrid, Spain..

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  • Title: EUROBIOSYN - A modular platform for biosynthesis of complex molecules
    Descriptive info: The eurobiosyn project is structured into the following workpackages.. WP1: Switch for directed re-programming of bacterial proteome.. WP2: Advanced catalyst design and production.. WP3: Identification of productivity constraints in SBTs.. WP4: Design of optimised enzymes.. WP5: Project management and dissemination.. The prime objective of this Work Package is the development of a switch for directed re-programming of the bacterial proteome.. This will be achieved through (1) the development of a general procedure for in silico design and engineering target sites for viral proteases within permissive loops of given bacterial target proteins, (2) Insertion of multiple.. SceI.. -sites through the chromosome of a recipient target strain and (3) engineering of a phage lambda-based genetic switch able to simultaneously enhance expression of desired enzyme, inactivate target proteins/activities, and trigger chromosome destruction.. The goal of this Work Package is the overall SBT-design and application, comprising (1) the identification and qualification of host genes that potentially interfere with monosaccharide production and (2) SBT production and application.. Once the first SBT is isolated from the remaining metabolic network, it will still obey the enzymatic constraints  ...   also allow product accumulation.. The identification of productivity constraints in the isolated SBT will be achieved through a detailed system analysis of a SBT using highly dynamically resolved experimental data, stochastic grey-box modelling and optimal experimental design tools as well as mathematical optimisation of SBT productivity.. Bottlenecks in the SBT originating from enzymes with insufficient stability, activity, or inhibition by substrate or product will be removed by protein engineering of these enzymes or by replacing them by homologues with desired properties.. Project Management has the objective to coordinate the overall technological progress, administration and finances of the project, to communicate with the EU commission and to coordinate and supervise the multidisciplinary team of four European Partners to realise deliverables and milestones according to the Work Plan.. The second part of objectives is to establish a framework for the efficient dissemination of the results of EUROBIOSYN, to generate wide visibility for the Project and its results and to establish the conditions and network for a larger European SYNTHETIC BIOLOGY initiative that should result in the application for a NoE or an IP..

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  • Title: EUROBIOSYN - A modular platform for biosynthesis of complex molecules
    Descriptive info: paper.. Schümperli M.. , Pellaux R.. , Panke S.. Chemical and enzymatic routes do dihydroxyacetone phosphate.. Appl Microbiol Biotechnol (2007) 75:33-45.. Davidescu F.. P.. , Madsen H.. , Jørgensen S.. B.. Systematic qualitative experimental design based upon identifiability analysis.. ESCAPE 17 2007, Conference Review, Elsevier.. Pleiss, J.. The promise of synthetic biology.. Appl Microbiol Biotechnol (2006) 73:735-739.. poster.. Schümperli, M.. , Pellaux, R.. , Panke, S.. , Knoll, M.. , Pleiss, J.. , Calles, B.. , de lorenzo, V.. , Davidescu, F.. 2007.. A Modular Platform for Biosynthesis of Complex Molecules.. Poster presentation, Synthetic Biology 3.. 0, Zürich, Switzerland, 24.. -27.. 06.. 2007.. Davidescu, F.. , Madsen, H.. Qualitative experimental design.. Calles, B.. , de Lorenzo, V.. Genetic tools for re-routing metabolic pathways in.. Escherichia coli.. Knoll, M.. From Sequence to Function: Understanding and Engineering Enzymes by  ...   Berkeley, USA, 21.. -23.. 05.. 2005.. Grey-box stochastic modelling of continuous cultures of.. Aspergillus oryzae.. Poster presentation, 12th European Congress on Biotechnology, Copenhagen, Denmark, 21.. -24.. 08.. 2005.. Kümmel A.. , Schümperli M.. Design of a system of biotransformations by means of stoichiometric network analysis.. oral presentations.. Madsen, H.. Qualitative experimental design for an enzymtic reaction network.. Oral presentation, ESCAPE 17, Bucharest, Romania, 27.. -30.. Oral presentation, Multistep Enzyme Catalysed Processes (MECP06), Graz, Austria, 18.. -21.. 04.. , Gomolka S.. A new approach for the synthesis of DHAP: The system of biotransformations.. Oral presentation, 12th European Congress on Biotechnology, Copenhagen, Denmark, 21.. Heinemann M.. Synthetic Biology: Putting engineering into bioengineering.. Oral presentation, BioPerspectives 2005, Wiesbaden, 10.. -12.. , Gomolka A.. Genome-based design of a system of biotransformations.. Oral presentation, GVC/DECHEMA-Vortragstagung Systembiotechnologie für industrielle Prozesse , Braunschweig, 01.. -04..

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  • Title: EUROBIOSYN - A modular platform for biosynthesis of complex molecules
    Descriptive info: From cell to factory.. For the first time a team of researchers at ETH Zurich is co-ordinating a project funded by the European Union.. Together with researchers from the universities.. english.. version.. german version.. Die NEST-Pathfinder-Initiative.. Angeführt von Forschern renommierter Universitäten wie dem Massachusetts Institute of Technology, der Princeton und der Duke University formiert sich seit etwa zwei Jahren in den USA.. german.. french version.. A sweeter way to make saccharides.. Industrial methods to manufacture even simple saccharide structures are extremely complex and expensive.. Living cells, meanwhile, readily synthesise saccharides using enzymes..

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  • Title: EUROBIOSYN - A modular platform for biosynthesis of complex molecules
    Descriptive info: For access to the internal pages enter username and password:.. username:.. password:..

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  • Title: EUROBIOSYN - A modular platform for biosynthesis of complex molecules
    Descriptive info: Utilising a synthetic biology approach, EUROBIOSYN targets the construction of a modular platform for the highly efficient synthesis of complex saccharide structures for which no economic synthesis scheme exists to date.. We will use a forward engineering approach in order.. to modularise Escherichia coli's cell metabolism into an energy module and a synthetic module for saccharide production and.. to adapt the modules' productivity by reengineering its key enzymes.. However, such a cell modularisation is incompatible with cell viability,  ...   essentially wild-type E.. coli cell, the flipping of a switch will induce the second phase's modularisation through a major reorganisation of the cellular proteome, and only the resulting "system of biotransformations" will be used for saccharide production in the third phase.. We will demonstrate the feasibility of the concept with the one-pot, one-step production of dihydroxyacetone phosphate (DHAP)-derived monosaccharides for pharmaceutical applications.. By adding more modules in the future, we target the facile and inexpensive design of inaccessible oligosaccharides..

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  • Title: EUROBIOSYN - A modular platform for biosynthesis of complex molecules
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  • Archived pages: 10